Tooth Agenesis
نویسندگان
چکیده
Tooth agenesis denotes a condition where teeth are missing due to a developmental failure. According to severity, this malformation can be subdivided into hypodontia, oligodontia and anodontia. With a frequency of 20–30%, tooth agenesis is the most prevalent dental dysplasia, but not all teeth are equally affected. Familial occurrence and concordance in twins indicate potential genetic causes. Thus far, mutations could be identified for the genes MSX1, PAX9 and AXIN2. All result in oligodontia. It is assumed that the defects cause haploinsufficiency, reducing the functional gene products below a critical level, which is required for normal odontogenesis. Both hypodontia and oligodontia can occur as an isolated dental malformation or in combination with defects in other organs, for example the skin and its appendages. Such syndromes can result from genetic defects affecting MSX1 and the EDA signalling pathway. In the case of isolated hypodontia, associations have been found with sequence variants of several genes.
منابع مشابه
Radiographic Evaluation of Dental Development in Patients With Tooth Agenesis
Introduction: Hypodontia is one of the most common developmental anomalies. This study aimed to evaluate the variations of radiographic dental development in a group of Iranian children with dental agenesis. Materials and Methods: This study evaluated 1230 Orthopantomographs (OPGs) for agenesis of permanent teeth obtained from the patients aged between 8 and 18 years. Then the difference betwe...
متن کاملبررسی رابطه موتاسیون ژن MSX1 با Tooth Agenesis با روش مولکولی RFLP-PCR
زمینه و هدف: با توجه به نقش پر اهمیت ژنتیک در تکوین آنومالیهای دندانی به ویژه عدم تشکیل جوانه دندانی شناسایی جهش ژنتیکس در افراد مبتلا به Tooth Agenesis (T.A) حائز اهمیت بوده، تشخیص پیش بالینی و درمان بهتر ارتودنسی را مقدور می سازد. هدف از این مطالعه بررسی رابطه موتاسیون ژن MSX1 با Tooth genesis می باشد.مواد و روشها: تحقیق به روش مورد – شاهدی (case – control) صورت گرفت. گروه مورد شامل 20 فرد مب...
متن کاملThe Association Between Dental Anomalies and Hypodontia Among 9-20 years Old Individuals in Ardabil City, Iran: A Causal-Comparative Study
Introduction: This study aimed to investigate the relationship between the prevalence of dental anomalies and hypodontia. Materials and Methods: In this retrospective study, the panoramic radiographs of 101 cases with tooth agenesis (except for the third molar) were studied and compared with [Pn1] those of a non-agenesis control group of 182 subjects. The subjects were within the age range of ...
متن کاملA study of prevalence and distribution of tooth agenesis
INTRODUCTION Tooth agenesis is a phenomenon that occurs relatively commonly. The incidence of the missing teeth presented in the previous reports varies according to the studied population. OBJECTIVE The aim of this study was to find the prevalence of tooth agenesis in a population group in Bucharest. METHODS AND RESULTS The prevalence and distribution of dental agenesis was determined in a...
متن کاملAgenesis of Mandibular Second Premolar
Tooth agenesis is the most common of all dental developmental disorders. The mandibular second premolars are the teeth most commonly found missing (2.2 to 4.1%) after the third molars. There are more studies on tooth agenesis than the other malformations but yet they are limited. This article reviews the studies related to agenesis of mandibular second premolars and the underlying mechanisms be...
متن کاملImpacted Primary Tooth and Tooth Agenesis: A Case Report of Monozygotic Twins
In the present report, a case of 19 year-old monozygotic twin brothers with similar tooth agenesis and impacted primary teeth is presented. Both twins (HDH, DHH) had agenesis of ten and eleven teeth (respectively), third molars excluded, consistent with oligodontia and both had four impacted primary teeth and the permanent successors of all these primary teeth were congenitally missing. The occ...
متن کامل